![]() ![]() Limitations: There may be studies not captured by the defined search criteria. Among these studies, there were four RCTs, two open-label single-arm studies, one randomized, double-blind crossover study, and one two-arm open-label study with crossover. The studies evaluated probiotics ( n = 5), therapeutic diet ( n = 1), and herbal medicines ( n = 2). Results: Eight studies met inclusion criteria. Study Appraisal: The following information was extracted from the selected studies: study type, study participants, SIBO subtype, intervention, comparison, outcome measures, relevant results, relevant side effects, and Jadad score. Randomized controlled trials (RCTs), nonrandomized clinical trials with or without a control, and crossover studies were included. ![]() Alternative interventions were defined as an intervention that included a probiotic supplement, herbal preparation, or a dietary change. Study Eligibility Criteria: Human studies in which an alternative intervention was used to treat SIBO were included. Objectives: The objective of this review is to evaluate the role of alternative therapies in SIBO treatment.ĭata Sources: EMBASE, MEDLINE, and the Cochrane Central Register were systematically searched for clinical studies evaluating alternative therapies in the management of SIBO. Alternative therapies such as probiotics, therapeutic diets, and herbal medicines have been used to individualize SIBO management, particularly in recalcitrant cases. However, many antibiotics have a considerable side-effect profile and SIBO commonly reoccurs after successful eradication with antibiotics. Background: Broad-spectrum antibiotics are the first-line treatment for small intestinal bacterial overgrowth (SIBO). ![]()
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