![]() ![]() Chapter 1 provides an introduction to stroke with a particular focus on pathophysiological mechanisms and pathways which may provide clues as to which candidate gene systems are implicated in stroke. This book is intended as an introduction to stroke genetics for both the interested clinician seeing stroke patients, and the basic scientist entering this field of research. The availability of current neuroimaging and other investigation techniques for accurately classifying stroke phenotype, in combination with the revolution in genotyping technology and statistical analysis, makes this a highly fruitful area for future research. Recently the location of the first stroke specific gene (STRK1), acting independently of conventional risk factors, has been described. An increasing number of studies, primarily candidate gene association studies, have suggested possible genetic risk factors for multifactorial stroke. A small proportion of stroke cases are caused by single gene disorders and the genetic basis of a number of these has been described in recent years including CADASIL, perhaps the most common monogenic cause of ischaemic stroke. Increasing evidence suggests that genetic factors are important in the stroke risk, often via interactions with conventional risk factors. However, the situation is beginning to change. Despite its importance on a population basis, research into the genetics of stroke, particularly for multifactorial stroke, has lagged behind that for other polygenic disorders such as diabetes, asthma, and ischaemic heart disease. ![]() In addition to stroke, cerebrovascular disease causes vascular dementia, which is the second commonest cause of dementia after Alzheimer’s disease. It is the major cause of adult neurological disability in the developed world, and in most countries the third most common cause of adult mortality. Stroke causes an enormous health burden in both developed and developing societies. Enquiries concerning reproduction outside the scope of the above should be sent to the Rights Department, Oxford University Press, at the address above You must not circulate this book in any other binding or cover and you must impose this same condition on any acquirer A catalogue record for this title is available from the British Library Library of Congress Cataloging in Publication Data (Data available) ISBN 0 19 8515863 (Hbk) 10 9 8 7 6 5 4 3 2 1 Typeset by Newgen Imaging Systems (P) Ltd., Chennai, India Printed in Great Britain on acid-free paper by T. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, without the prior permission in writing of Oxford University Press, or as expressly permitted by law, or under terms agreed with the appropriate reprographics rights organization. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide in Oxford New York Auckland Bangkok Buenos Aires Cape Town Chennai Dar es Salaam Delhi Hong Kong Istanbul Karachi Kolkata Kuala Lumpur Madrid Melbourne Mexico City Mumbai Nairobi São Paulo Shanghai Taipei Tokyo Toronto Oxford is a registered trade mark of Oxford University Press in the UK and in certain other countries Published in the United States by Oxford University Press Inc., New York © Oxford University Press, 2003 © Hugh Markus Figures 1.3, 1.4b, 1.6, 1.7, 2.1, 2.2a, 2.2b, 6.2, 8.1, 8.2, 8.4, 10.3A–C, 13.1–8 The moral rights of the authors have been asserted Database right Oxford University Press (maker) First published 2003 All rights reserved. Great Clarendon Street, Oxford OX2 6DP Oxford University Press is a department of the University of Oxford. Markus Clinical Neuroscience, St George’s Hospital Medical School, London, UK The information in this book is intended to be useful to the general reader, but should not be used as a means of self-diagnosis or for the prescription of medication. Readers are urged to take appropriately qualified medical advice in all cases. Whilst every effort has been made to ensure that the contents of this book are as complete, accurate and up to date as possible at the date of writing, Oxford University Press is not able to give any guarantee or assurance that such is the case. Oxford Medical Publications Stroke Genetics ![]()
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